Socially awkward and sexually inexperienced, Otis Milburn wants to get through his last two years of high school without any troubles. While everyone else appears to have matured over the summer break, he only becomes more aware of his own shortcomings. Furthermore, his mother's occupation as a sex therapist is exposed to the entire student body, shaping Otis' final years to be anything but quiet.

When Otis suffers a panic attack following the revelation of his biggest secret, help comes from Maeve Wiley, a brilliant girl with a disdainful attitude and bad reputation. Once Otis regains his composure, the duo stumble upon resident bully Adam Groff having a sexual crisis, and Otis ends up gently guiding him to a resolution.

Maeve immediately notices Otis' gift for "fixing" people's sexual dysfunctions and approaches him with a lucrative proposal: to establish a secret sex-therapy clinic at their school. Although reluctant, Otis soon finds himself advising his fellow students in various sexual predicaments, as well as growing closer to his reclusive new business partner.

[Written by MAL Rewrite]